Extracellular NAD and ATP: Partners in immune cell modulation
نویسندگان
چکیده
منابع مشابه
Stem Cell-Derived Extracellular Vesicles and Immune-Modulation
Extra-cellular vesicles (EVs) are bilayer membrane structures enriched with proteins, nucleic acids, and other active molecules and have been implicated in many physiological and pathological processes over the past decade. Recently, evidence suggests EVs to play a more dichotomic role in the regulation of the immune system, whereby an immune response may be enhanced or supressed by EVs dependi...
متن کاملHydrolysis of extracellular ATP and immune suppression: humans versus mice
1. Zimmerman SA, Schultz WH, Burgett S, Mortier NA, Ware RE. Hydroxyurea therapy lowers transcranial doppler flow velocities in children with sickle cell anemia. Blood. 2007;110:1043-1047. 2. Pegelow CH, Adams RJ, McKie V, et al. Risk of recurrent stroke in patients with sickle cell disease treated with erythrocyte transfusions. J Pediatr. 1995;126(6):896-899. 3. Scothorn DJ, Price C, Schwartz ...
متن کاملHydrolysis of extracellular ATP and immune suppression: humans versus mice.
1. Zimmerman SA, Schultz WH, Burgett S, Mortier NA, Ware RE. Hydroxyurea therapy lowers transcranial doppler flow velocities in children with sickle cell anemia. Blood. 2007;110:1043-1047. 2. Pegelow CH, Adams RJ, McKie V, et al. Risk of recurrent stroke in patients with sickle cell disease treated with erythrocyte transfusions. J Pediatr. 1995;126(6):896-899. 3. Scothorn DJ, Price C, Schwartz ...
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The secretion of ATP by stimulated nerves is well documented. Following repetitive stimulation, extracellular ATP at the synapse can accumulate to levels estimated to be well over 100 microM. The present study examined the effects of extracellular ATP in the concentration range of 0.1-1.0 mM on second-messenger-generating systems in cultured neural cells of the clones NG108-15 and N1E-115. Cell...
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T and B lymphocytes play a central role in protecting the human body from infectious pathogens but occasionally they can escape immune tolerance, become activated, and induce autoimmune diseases. All deregulated cellular processes are associated with improper functioning of the ubiquitin-proteasome system (UPS) in eukaryotic cells. The role of ubiquitin in regulation of immune responses and in ...
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ژورنال
عنوان ژورنال: Purinergic Signalling
سال: 2007
ISSN: 1573-9538,1573-9546
DOI: 10.1007/s11302-006-9038-7